TY  - JOUR
PY  - 2015//
TI  - Fatal mechanical asphyxia induces changes in energy utilization in the rat brain: an (18)F-FDG-PET study
JO  - Legal medicine (Elsevier)
A1  - Ma, Suhua
A1  - You, Shengzhong
A1  - Hao, Li
A1  - Zhang, Dongchuan
A1  - Quan, Linda
SP  - 239
EP  - 244
VL  - 17
IS  - 4
N2  - PURPOSE: This study was designed to evaluate changes in brain glucose metabolism in rats following ligature strangulation. <br><br>MATERIALS AND METHODS: Thirteen male Wistar rats were used in the present study, divided into control (n=7) and asphyxia groups (n=6, ligature strangulation). Positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-d-glucose ((18)F-FDG) was used to evaluate brain glucose metabolism. Rats were scanned for PET-CT, and image data co-registered with a T2WI MRI template using SPM8 software. Image J was employed to draw regions of interest (ROIs) from the MRI template and acquire ROI activity information from the PET images. <br><br>RESULTS: In the asphyxia group vs. controls, (18)F-FDG uptake (FU) was decreased in the substantia nigra (25.26%, p<0.001), rhombencephalon (pons/medulla oblongata, 13.92%, p<0.01), hypothalamus (22.06%, p<0.01), ventral tegmentum (10.12%, p<0.05) and amygdala (12.74%, p<0.05); however, FU was increased in motor (18.21%, p<0.05) and visual cortices (19.2%, p<0.05). <br><br>CONCLUSIONS: The glucose metabolism distribution map in the asphyxiated rat brains were substantially changed versus controls. PET with (18)F-FDG can demonstrate excitement and inhibition of different brain areas even in cases of ligature strangulation.<p />  <p>Language: en</p>
LA  - en
SN  - 1344-6223
UR  - http://dx.doi.org/10.1016/j.legalmed.2015.02.002
ID  - ref1
ER  -