TY  - JOUR
PY  - 2015//
TI  - Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury
JO  - Biological psychology
A1  - Bailey, N. W.
A1  - Hoy, K. E.
A1  - Maller, J. J.
A1  - Upton, D. J.
A1  - Segrave, R. A.
A1  - Fitzgibbon, B. M.
A1  - Fitzgerald, P. B.
SP  - 1
EP  - 10
VL  - 106
IS  - 
N2  - Impaired error awareness is related to poorer outcome following a traumatic brain injury (TBI). Deficits in error awareness are also found in major depressive disorder (MDD). However, neural measures of impairments in error awareness have not been examined in the MDD that commonly follows a TBI (TBI-MDD). These measures may be a marker for the development of TBI-MDD. The current study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded-healthy controls (n=15), MDD-only (n=15), TBI-only (n=16), and TBI-MDD (n=12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed a significantly less frontally distributed neural activity, suggesting reduced contribution from frontal generating brain sources in TBI-MDD. Neural activity during this time window has been suggested by previous research to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected. This study provides evidence for neurophysiological differences in error processing that are unique to TBI-MDD. The altered distribution may reflect an impaired ability to synchronize frontal neural activity in response to errors, resulting in reduced conscious awareness of errors. However, the lack of early processing differences suggests early error detection itself is intact. This study highlights the importance of treatments focusing on error awareness for individuals with TBI-MDD.<p />  <p>Language: en</p>
LA  - en
SN  - 0301-0511
UR  - http://dx.doi.org/10.1016/j.biopsycho.2015.01.011
ID  - ref1
ER  -