TY - JOUR
PY - 2014//
TI - Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex- specific effects
JO - Behavioural brain research
A1 - Shanks, Ryan A.
A1 - Ross, Jordan M.
A1 - Doyle, Hillary H.
A1 - Helton, Amanda K.
A1 - Picou, Brittany D.
A1 - Schulz, Jordyn
A1 - Tavares, Chris
A1 - Bryant, Sarah
A1 - Dawson, Bryan L.
A1 - Lloyd, Steven A.
SP - 116
EP - 124
VL - 281
IS -
N2 - The increasing availability, over-prescription, and misuse and abuse of ADHD psychostimulant medications in adolescent populations necessitates studies investigating the long-term effects of these drugs persisting into adulthood. Male and female C57Bl/6J mice were exposed to amphetamine (AMPH) (1.0 and 10mg/kg), methylphenidate (MPD) (1.0 and 10mg/kg), or cocaine (COC) (5.0mg/kg) from postnatal day 22 to 31, which represents an early adolescent period. After an extended period of drug abstinence, adult mice were challenged with a subacute methamphetamine (METH) dose (0.5mg/kg), to test the long-term effects of adolescent drug exposures on behavioral cross-sensitization using an open field chamber. There were no sex- or dose-specific effects on motor activity in adolescent, saline-treated controls. However, AMPH, MPD, and COC adolescent exposures induced cross-sensitization to a subacute METH dose in adulthood, which is a hallmark of addiction and a marker of long-lasting plastic changes in the brain. Of additional clinical importance, AMPH-exposed male mice demonstrated increased cross-sensitization to METH in contrast to the female-specific response observed in MPD-treated animals. There were no sex-specific effects after adolescent COC exposures. This study demonstrates differential drug, dose, and sex-specific alterations induced by early adolescent psychostimulant exposure, which leads to behavioral alterations that persist into adulthood. Language: en
LA - en
SN - 0166-4328
UR - http://dx.doi.org/10.1016/j.bbr.2014.12.002
ID - ref1
ER -