TY  - JOUR
PY  - 2014//
TI  - The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger
JO  - Neuron
A1  - Amo, Ryunosuke
A1  - Fredes, Felipe
A1  - Kinoshita, Masae
A1  - Aoki, Ryo
A1  - Aizawa, Hidenori
A1  - Agetsuma, Masakazu
A1  - Aoki, Tazu
A1  - Shiraki, Toshiyuki
A1  - Kakinuma, Hisaya
A1  - Matsuda, Masaru
A1  - Yamazaki, Masako
A1  - Takahoko, Mikako
A1  - Tsuboi, Takashi
A1  - Higashijima, Shin-Ichi
A1  - Miyasaka, Nobuhiko
A1  - Koide, Tetsuya
A1  - Yabuki, Yoichi
A1  - Yoshihara, Yoshihiro
A1  - Fukai, Tomoki
A1  - Okamoto, Hitoshi
SP  - 1034
EP  - 1048
VL  - 84
IS  - 5
N2  - Anticipation of danger at first elicits panic in animals, but later it helps them to avoid the real threat adaptively. In zebrafish, as fish experience more and more danger, neurons in the ventral habenula (vHb) showed tonic increase in the activity to the presented cue and activated serotonergic neurons in the median raphe (MR). This neuronal activity could represent the expectation of a dangerous outcome and be used for comparison with a real outcome when the fish is learning how to escape from a dangerous to a safer environment. Indeed, inhibiting synaptic transmission from vHb to MR impaired adaptive avoidance learning, while panic behavior induced by classical fear conditioning remained intact. Furthermore, artificially triggering this negative outcome expectation signal by optogenetic stimulation of vHb neurons evoked place avoidance behavior. Thus, vHb-MR circuit is essential for representing the level of expected danger and behavioral programming to adaptively avoid potential hazard.<p /> <p>Language: en</p>
LA  - en
SN  - 0896-6273
UR  - http://dx.doi.org/10.1016/j.neuron.2014.10.035
ID  - ref1
ER  -