TY  - JOUR
PY  - 1987//
TI  - A dose-response model incorporating nonlinear kinetics
JO  - Biometrics
A1  - Van Ryzin, J.
A1  - Rai, K.
SP  - 95
EP  - 105
VL  - 43
IS  - 1
N2  - This paper introduces a dose-response model for toxic quantal response data based on hit theory applied to the dose unit as transformed by a nonlinear kinetic equation. When spontaneous background response is included in the model, the resulting dose-response model has four parameters. The maximum likelihood estimators and their large-sample properties are given. Likelihood ratio tests of interest are developed, including one for whether the model is one-hit in the transformed dose and one to check whether nonlinear kinetics is operative. The use of the model for low-dose extrapolation is presented. Finally, the procedures developed are illustrated on data from three animal carcinogenicity bioassays that show, respectively, concave, linear, and convex dose-response curves in the observed data.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-341X
UR  - http://dx.doi.org/
ID  - ref1
ER  -