TY  - JOUR
PY  - 2014//
TI  - Amygdala activation and emotional processing in adolescents at risk for substance use disorders
JO  - Journal of child and adolescent substance abuse
A1  - Lindsay, Dawn L.
A1  - Pajtek, Stefan
A1  - Tarter, Ralph E.
A1  - Long, Elizabeth C.
A1  - Clark, Duncan B.
SP  - 200
EP  - 204
VL  - 23
IS  - 3
N2  - Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t = 2.76, df = 6, p = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.<p />  <p>Language: en</p>
LA  - en
SN  - 1067-828X
UR  - http://dx.doi.org/10.1080/1067828X.2014.889515
ID  - ref1
ER  -