TY  - JOUR
PY  - 1989//
TI  - Pharmacokinetics of pralidoxime chloride. A comparative study in healthy volunteers and in organophosphorus poisoning
JO  - Archives of toxicology
A1  - Jovanovic, D.
SP  - 416
EP  - 418
VL  - 63
IS  - 5
N2  - The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides. The elevation of plasma concentrations of the oxime and prolongation of its "effective half-life" were noticed in poisoned individuals. These changes were attributed to the disturbed general hemodynamics and reduced renal blood flow in organophosphorus intoxication rather than to the direct renal toxicity of anticholinesterases.<p /> <p>Language: en</p>
LA  - en
SN  - 0340-5761
UR  - http://dx.doi.org/
ID  - ref1
ER  -