TY  - JOUR
PY  - 2014//
TI  - Prediction of post-earthquake depressive and anxiety symptoms: a longitudinal resting-state fMRI study
JO  - Scientific reports
A1  - Long, Jinyi
A1  - Huang, Xiaoqi
A1  - Liao, Yi
A1  - Hu, Xinyu
A1  - Hu, Junmei
A1  - Lui, Su
A1  - Zhang, Rui
A1  - Li, Yuanqing
A1  - Gong, Qiyong
SP  - 6423
EP  - 6423
VL  - 4
IS  - 
N2  - Neurobiological markers of stress symptom progression for healthy survivors from a disaster (e.g., an earthquake) would greatly help with early intervention to prevent the development of stress-related disorders. However, the relationship between the neurobiological alterations and the symptom progression over time is unclear. Here, we examined 44 healthy survivors of the Wenchuan earthquake in China in a longitudinal resting-state fMRI study to observe the alterations of brain functions related to depressive or anxiety symptom progression. Using multi-variate pattern analysis to the fMRI data, we successfully predicted the depressive or anxiety symptom severity for these survivors in short- (25 days) and long-term (2 years) and the symptom severity changes over time. Several brain areas (e.g., the frontolimbic and striatal areas) and the functional connectivities located within the fronto-striato-thalamic and default-mode networks were found to be correlated with the symptom progression and might play important roles in the adaptation to trauma.<p />  <p>Language: en</p>
LA  - en
SN  - 2045-2322
UR  - http://dx.doi.org/10.1038/srep06423
ID  - ref1
ER  -