TY  - JOUR
PY  - 1989//
TI  - Cardiovascular, metabolic and neurologic effects of acute carbon monoxide poisoning in the rat
JO  - Toxicology letters
A1  - Penney, D. G.
A1  - Verma, K.
A1  - Hull, J. A.
SP  - 207
EP  - 213
VL  - 45
IS  - 2-3
N2  - Acute severe carbon monoxide poisoning was investigated in a modified Levine preparation. The rats inhaled 2700 p.p.m. CO for 90 min (COHb = 80%). Body temperature, heart rate and carotid systemic and 'stump' blood pressure declined sharply during CO exposure. By 2 and 4 h post-CO, body temperature and blood pressure had not renormalized, while heart rate was elevated. Blood glucose was unchanged at termination of CO exposure, but increased from 115 mg/dl to 191 mg/dl by 2 h post-CO. Hematocrit increased significantly during CO exposure, but no change in plasma volume was observed. Many rats showed one-sided muscle weakness and unidirectional rotation. By 4 h post-CO, behaviorally-assessed neurologic deficit was strongly correlated with an increase in left cerebral hemisphere water content, demonstrating a direct relationship between brain edema and dysfunction resulting from CO poisoning.<p /> <p>Language: en</p>
LA  - en
SN  - 0378-4274
UR  - http://dx.doi.org/
ID  - ref1
ER  -