TY  - JOUR
PY  - 2014//
TI  - Behavioral and psychological symptoms in Alzheimer's disease
JO  - BioMed research international
A1  - Li, Xiao-Ling
A1  - Hu, Nan
A1  - Tan, Meng-Shan
A1  - Yu, Jin-Tai
A1  - Tan, Lan
SP  - e927804
EP  - e927804
VL  - 2014
IS  - 
N2  - Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis are now recognized as core features of Alzheimer's disease (AD), and there is a general consensus that greater symptom severity is predictive of faster cognitive decline, loss of independence, and even shorter survival. Whether these symptoms result from the same pathogenic processes responsible for cognitive decline or have unique etiologies independent of AD-associated neurodegeneration is unclear. Many structural and metabolic features of the AD brain are associated with individual neuropsychiatric symptoms or symptom clusters. In addition, many genes have been identified and confirmed that are associated with symptom risk in a few cases. However, there are no single genes strongly predictive of individual neuropsychiatric syndromes, while functional and structural brain changes unique to specific symptoms may reflect variability in progression of the same pathological processes. Unfortunately, treatment success for these psychiatric symptoms may be lower when comorbid with AD, underscoring the importance of future research on their pathobiology and treatment. This review summarizes some of the most salient aspects of NPS pathogenesis.<p />  <p>Language: en</p>
LA  - en
SN  - 2314-6133
UR  - http://dx.doi.org/10.1155/2014/927804
ID  - ref1
ER  -