TY  - JOUR
PY  - 1987//
TI  - Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Runnegar, M. T.
A1  - Andrews, J.
A1  - Gerdes, R. G.
A1  - Falconer, I. R.
SP  - 1235
EP  - 1239
VL  - 25
IS  - 11
N2  - The freshwater, bloom forming cyanobacterium (blue-green alga) Microcystis aeruginosa produces a peptide hepatotoxin which causes death accompanied by liver necrosis. We show here that the time and dose-dependent blebbing of isolated hepatocytes is accompanied by the activation of phosphorylase a, with no changes in cyclic AMP levels, and by glutathione (acid-soluble thiols) depletion. These results suggest that the disruption of cytoskeletal structures is accompanied by disturbances in cellular calcium homeostasis and by decreased protection against oxidative damage to the cells.<p /> <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/
ID  - ref1
ER  -