TY  - JOUR
PY  - 2014//
TI  - Use of non-benzodiazepine sedative hypnotics and risk of falls in older men
JO  - Journal of gerontology and geriatric research
A1  - Diem, Susan J.
A1  - Ewing, Susan K.
A1  - Stone, Katie L.
A1  - Ancoli-Israel, Sonia
A1  - Redline, Susan
A1  - Ensrud, Kristine E.
SP  - e1000158
EP  - e1000158
VL  - 3
IS  - 3
N2  - BACKGROUND: To ascertain whether use of non-benzodiazepine sedative-hypnotics is associated with risk of falls and compare this to risk of falls associated with use of benzodiazepines. <br><br>METHODS: Among 4450 community-dwelling men, aged 71 years and older, enrolled in the population-based prospective cohort study, Osteoporotic Fractures in Men (MrOS), use of non-benzodiazepine sedative-hypnotics and benzodiazepines was assessed by interview and verified from medication containers at the third annual visit of the MrOS study. Falls in the subsequent one-year period were ascertained by tri-annual questionnaires and a computerized dictionary used to categorize type of medication. <br><br>RESULTS: In age-adjusted models, non-benzodiazepine sedative hypnotic use was associated with an increased risk of any falls (one or more falls) (RR 1.44, 95% CI 1.15, 1.81) and recurrent falls (2 or more falls) (RR 1.51, 95% CI 1.07, 2.14). Use of benzodiazepines was associated with a similar increase in age-adjusted risk of falling. Depressive symptoms, inability to stand from a chair, and instrumental activities of daily living (IADL) impairment modestly attenuated these associations. The association between non-benzodiazepine sedative-hypnotic use and falls was most pronounced among men without a history of falls in the previous year: in a multivariable model controlling for multiple potential confounders, the RR of any falls was 1.74 (95% CI 1.13, 2.68) in this subgroup. <br><br>CONCLUSIONS: Use of non-benzodiazepine sedative-hypnotics is associated with an increased risk of falls. Nonpharmacologic approaches to sleep disturbances may represent the safest approach to sleep difficulties in older adults.<p />  <p>Language: en</p>
LA  - en
SN  - 2167-7182
UR  - http://dx.doi.org/10.4172/2167-7182.1000158
ID  - ref1
ER  -