TY  - JOUR
PY  - 1979//
TI  - Increased survival in experimental dog heatstroke after reduction of gut flora
JO  - Aviation, space, and environmental medicine
A1  - Bynum, G.
A1  - Brown, J.
A1  - Dubose, D.
A1  - Marsili, M.
A1  - Leav, I.
A1  - Pistole, T. G.
A1  - Hamlet, M.
A1  - LeMaire, M.
A1  - Caleb, B.
SP  - 816
EP  - 819
VL  - 50
IS  - 8
N2  - A study was undertaken to determine if gut flora contribute to the pathophysiology of experimental canine heatstroke. Fifty animals in four groups were anesthetized with sodium pentobarbital (25 mg/kg) intravenously. An air temperature of 42-46 degrees C was maintained adjacent to the dog with a water-heated blanket for approximately 2 h until rectal temperatures rose to 43.5 +/- 0.4 degrees C. Animals were then cooled passively in room air (28 degrees C, 20% RH) until death or until 18 h elapsed, and were euthanized. Reduction of intestine stool and bacterial contents with antibiotics, cathartics, and enemas prior to heatstroke increased the incidence of 18-h survival from 20.0% to 70.6%; antibiotics administered after heatstroke did not alter the incidence of survival over control values. These data suggest that gut flora, presumably through endotoxemia, contribute to the evolution of heatstroke pathophysiology.<p /> <p>Language: en</p>
LA  - en
SN  - 0095-6562
UR  - http://dx.doi.org/
ID  - ref1
ER  -