TY  - JOUR
PY  - 2014//
TI  - Changes in functional brain networks following sports related concussion in adolescents
JO  - Journal of neurotrauma
A1  - Virji-Babul, Naznin
A1  - Hilderman, Courtney
A1  - Makan, Nadia
A1  - Liu, Aiping
A1  - Smith-Forrester, Jenna
A1  - Franks, Chris
A1  - Wang, J. Z.
SP  - 1914
EP  - 1919
VL  - 31
IS  - 23
N2  - Sports related concussion is a major public health issue, however little is known about the underlying changes in functional brain networks in adolescents following injury. Our aim was to use the tools from graph theory to evaluate the changes in brain network properties following concussion in adolescent athletes. We recorded resting state electroencephalography (EEG) in thirty-three healthy adolescent athletes and nine adolescent athletes with a clinical diagnosis of sub-acute concussion. Graph theory analysis was applied to these data to evaluate changes in brain networks. Global and local metrics of the structural properties of the graph were calculated for each group, and correlated with ImPACT scores. There were no statistically significant differences in the global metrics between the groups; however, significant differences were found in the local metrics. Specifically in the concussed group we noted: a) increased values of betweenness and degree in frontal electrode sites corresponding to the (R) dorsolateral prefrontal cortex and the (R) inferior frontal gyrus and b) decreased values of degree in the region corresponding to the (R) frontopolar prefrontal cortex. In addition, there was significant negative correlation between degree and hub value with total symptom score at the electrode site corresponding to the (R) prefrontal cortex. This first preliminary report in adolescent athletes shows that resting state EEG combined with graph theoretical analysis may provide an objective method of evaluating changes in brain networks following concussion. This approach may be useful in identifying individuals at risk for future injury.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2014.3450
ID  - ref1
ER  -