TY  - JOUR
PY  - 1978//
TI  - Role of physical effort in the etiology of rat heatstroke injury and mortality
JO  - Journal of applied physiology: respiratory, environmental and exercise physiology
A1  - Hubbard, R. W.
A1  - Matthew, W. T.
A1  - Criss, R. E.
A1  - Kelly, C.
A1  - Sils, I.
A1  - Mager, M.
A1  - Bowers, W. D.
A1  - Wolfe, D.
SP  - 463
EP  - 468
VL  - 45
IS  - 3
N2  - A total of 171 untrained, unacclimatized, and unanesthetized rats were used to evaluate the effects of sedentary and work-induced hyperthermia on the incidence of mortality and cellular injury, 24 h postexposure. Cellular injury was defined as serum transaminase activity (SGPT and SGOT) exceeding 1,000 IU/l (heatstroke levels). Both the percent mortality and the percentage of 24-h survivors with transaminase levels above 1,000 IU/l were plotted against maximum core temperatures. Exertion-induced hyperthermia produced a significantly higher incidence of cellular injury and heatstroke death at lower core temperatures than hyperthermia alone. With hyperthermia only, the SGPT and SGOT dose-response curves were identical. When work was combined with hyperthermia, there was a greater incidence of elevated SGOT at lower core temperatures. These curves bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans. The results suggest a direct role of physical effort in causing heatstroke injury and mortality.<p /> <p>Language: en</p>
LA  - en
SN  - 0161-7567
UR  - http://dx.doi.org/
ID  - ref1
ER  -