TY  - JOUR
PY  - 2014//
TI  - Age-related changes in intracortical inhibition are mental-cognitive state-dependent
JO  - Biological psychology
A1  - Lysianne, Beynel
A1  - Alan, Chauvin
A1  - Nathalie, Guyader
A1  - Sylvain, Harquel
A1  - Christian, Marendaz
SP  - 9
EP  - 12
VL  - 101
IS  - 
N2  - INTRODUCTION: This study aimed to assess the impact of aging and 'state-dependency' on cortical excitability. Two studies investigated these factors using a motor task and found that the age-related differences observed at rest disappeared in the task condition. However, as both their tasks and excitability measurements involved the motorcortex, their results could be specific only to the motor system. To overcome this problem, the present study used a cognitive task to control mental state. <br><br>METHOD: Intracortical inhibition/facilitation (ICI/ICF) was assessed in young andolder adults at rest and during the cognitive task. The cortical silent period (CSP) was also evaluated. <br><br>RESULTS: ICI and CSP were reduced with aging. However, ICI differences between young and old people disappeared when they performed the cognitive task. <br><br>CONCLUSION: Age and mental state modify cortical excitability. Taking these factors into consideration is crucial to clinical research using cortical excitability as a possible biomarker of pathology.<p />  <p>Language: en</p>
LA  - en
SN  - 0301-0511
UR  - http://dx.doi.org/10.1016/j.biopsycho.2014.05.011
ID  - ref1
ER  -