TY  - JOUR
PY  - 2014//
TI  - Increased suicide attempts in young depressed patients with abnormal temporal-parietal-limbic gray matter volume
JO  - Journal of affective disorders
A1  - Peng, Hongjun
A1  - Wu, Kai
A1  - Li, Jiang
A1  - Qi, Haochen
A1  - Guo, Shengwen
A1  - Chi, Minyue
A1  - Wu, Xiaoming
A1  - Guo, Yangbo
A1  - Yang, Yuling
A1  - Ning, Yuping
SP  - 69
EP  - 73
VL  - 165
IS  - 
N2  - BACKGROUND: Suicide is a major cause of death throughout the world. Approximately 60% of all suicides have a history of depression. Previous studies of structural brain imaging have shown that suicide is often associated with abnormal fronto-limbic networks. However, the mechanism underlying suicide in depression remains poorly understood. <br><br>METHOD: Twenty sex- and age-matched suicidal unipolar patients were compared with 18 non-suicidal unipolar patients and 28 healthy controls. High-resolution T1-weighted 3T magnetic resonance imaging (MRI) scans were acquired. Hamilton Depressive Rating Scale (HAMD) and Self-Rating Depression scale (SDS) were evaluated. The criterion for suicidality was one or more documented lifetime suicide attempts. A whole-brain optimized voxel-based morphometry (VBM) approach was applied. The Dysfunctional Attitude Scale (DAS) was used to measure cognitive scheme in depressive patients. <br><br>RESULTS: Compared with controls, patients without suicide history showed significant decreased gray matter volume in the left insula lobe [-35 18 9], whereas patients with suicide history showed significantly decreased gray matter volume in the right middle temporal gyrus [60 -53 -8] and increased gray matter volume in the right parietal lobe [39 -39 60]. Compared with the non-suicidal depressed patient group, the suicidal group showed significant decreased gray matter volume in left limbic cingulated gyrus [-2 -21 28]. Moreover, the gray matter volume values in this significantly different brain region were negatively correlated with dysfunctional attitude scores in suicidal depressed patients. LIMITATIONS: This study needs replication and further clarification in a larger patient population. <br><br>CONCLUSIONS: Suicide attempts in young depressed patients may be related to abnormal gray matter volumes in temporal-parietal-limbic networks. Specifically, small left limbic cingulate gyrus volumes may be a candidate for the prediction of suicide in young depressed patients.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-0327
UR  - http://dx.doi.org/10.1016/j.jad.2014.04.046
ID  - ref1
ER  -