TY  - JOUR
PY  - 2014//
TI  - Role of hormonal levels on hospital mortality for male patients with severe traumatic brain injury
JO  - Brain injury
A1  - Hohl, Alexandre
A1  - Ronsoni, Marcelo Fernando
A1  - Debona, Rodrigo
A1  - Ben, Juliana
A1  - Schwarzbold, Marcelo Liborio
A1  - Diaz, Alexandre Paim
A1  - Thais, Maria Emília Rodrigues de Oliveira
A1  - Linhares, Marcelo Neves
A1  - Latini, Alexandra
A1  - Prediger, Rui Daniel Schroder
A1  - Pizzol, Felipe Dal
A1  - Walz, Roger
SP  - 1262
EP  - 1269
VL  - 28
IS  - 10
N2  - INTRODUCTION: Changes in hormone blood levels during the acute phase of traumatic brain injury (TBI) have been described in the literature. The objective was to investigate the association among several hormones plasma levels in the acute phase of severe TBI and the hospital mortality rate of male patients. <br><br>METHODS: The independent association among plasma levels of TSH, LH, FSH, GH, free T4, cortisol, IGF-1 and total testosterone was measured 10 hours and 30 hours after severe TBI and the hospital mortality of 60 consecutive male patients was evaluated. <br><br>RESULTS: At least one hormonal level abnormality was demonstrated in 3.6-73.1% of patients. The multiple logistic regressions showed a trend for an independent association among hospital mortality and normal or elevated LH levels measured at 10 hours (OR = 3.7, 95% CI = 0.8-16.3, p = 0.08) and 30 hours (OR = 3.9, 95% CI = 0.9-16.7, p = 0.06). Admission with abnormal pupils and a lower Glasgow Coma Score also were independently associated with hospital mortality. <br><br>CONCLUSION: The hormonal changes are frequent in the acute phase of severe TBI. The hormones plasma levels, excepting the LH, are not highly consistent with the hospital mortality of male patients.<p /> <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.3109/02699052.2014.915986
ID  - ref1
ER  -