TY  - JOUR
PY  - 1979//
TI  - Early biochemical liver changes following thiobenzamide poisoning
JO  - Toxicology
A1  - Chieli, E.
A1  - Malvaldi, G.
A1  - Tongiani, R.
SP  - 101
EP  - 114
VL  - 13
IS  - 2
N2  - Administration of thiobenzamide in a single dose (25 mg/100 g body wt by stomach tube) to male rats induced centrilobular necrosis, which became evident 10 h after the poisoning. In the meantime liver weight and water content underwent changes, glycogen was lost, triglycerides accumulated in the liver while decreasing in serum, [3H] leucine uptake in proteins was impaired and the activity of glucose-6-phosphatase and aminopyrine demethylase decreased. The activity of NADPH-cytochrome c reductase remained unchanged, whereas a reduction of the microsomal cytochrome P-450 occurred. The liver amount of reduced glutathione underwent no significant changes. Pretreatment of the animals with cobalt chloride or 20-methylcholanthrene decreased the liver damage caused by the drug. The in vitro addition of thiobenzamide to liver microsomes resulted in a spectral change. The appearance of conjugated dienes among microsomal lipids from drug-treated rats indicated for a lipoperoxidation taking place in vivo.<p /> <p>Language: en</p>
LA  - en
SN  - 0300-483X
UR  - http://dx.doi.org/
ID  - ref1
ER  -