TY  - JOUR
PY  - 1985//
TI  - Pathophysiologic effects of a toxic peptide from Microcystis aeruginosa
JO  - Toxicon: Journal of the International Society on Toxinology
A1  - Adams, W. H.
A1  - Stoner, R. D.
A1  - Adams, D. G.
A1  - Slatkin, D. N.
A1  - Siegelman, H. W.
SP  - 441
EP  - 447
VL  - 23
IS  - 3
N2  - Toxin-LR, a hexapeptide produced by Microcystis aeruginosa, causes marked hepatic vascular congestion, thrombocytopenia, microscopic pulmonary thrombi and death in 50-70 min when injected into mice. Although it is considered an hepatotoxin, we report that sublethal hepatocellular damage produced by CCl4 given 24 hr prior to toxin-LR administration prevents the acute deaths. However, CCl4-treated mice surviving toxin-LR acute effects often died during the subsequent three days. Pretreatment of mice with the microsomal enzyme inhibitors SKF 525A or cobaltous chloride did not alter the acute lethality of toxin-LR, but pharmacologic doses of hydrocortisone prevented both the acute and delayed deaths. X irradiation-induced thrombocytopenia or thrombocytopenia and leukopenia did not significantly affect the toxin's lethality. In vitro platelet aggregation or lysis did not occur during incubation with toxin-LR, nor was a humoral aggregating factor detected in plasma from toxin-injected mice.<p /> <p>Language: en</p>
LA  - en
SN  - 0041-0101
UR  - http://dx.doi.org/
ID  - ref1
ER  -