TY  - JOUR
PY  - 2014//
TI  - Proteomic study of differential protein expression in mouse lung tissues after aerosolized ricin poisoning
JO  - International journal of molecular sciences
A1  - Guo, Zhendong
A1  - Han, Chao
A1  - Du, Jiajun
A1  - Zhao, Siyan
A1  - Fu, Yingying
A1  - Zheng, Guanyu
A1  - Sun, Yucheng
A1  - Zhang, Yi
A1  - Liu, Wensen
A1  - Wan, Jiayu
A1  - Qian, Jun
A1  - Liu, Linna
SP  - 7281
EP  - 7292
VL  - 15
IS  - 5
N2  - Ricin is one of the most poisonous natural toxins from plants and is classified as a Class B biological threat pathogen by the Centers for Disease Control and Prevention (CDC) of U.S.A. Ricin exposure can occur through oral or aerosol routes. Ricin poisoning has a rapid onset and a short incubation period. There is no effective treatment for ricin poisoning. In this study, an aerosolized ricin-exposed mouse model was developed and the pathology was investigated. The protein expression profile in the ricin-poisoned mouse lung tissue was analyzed using proteomic techniques to determine the proteins that were closely related to the toxicity of ricin. 2D gel electrophoresis, mass spectrometry and subsequent biological functional analysis revealed that six proteins including Apoa1 apolipoprotein, Ywhaz 14-3-3 protein, Prdx6 Uncharacterized Protein, Selenium-binding protein 1, HMGB1, and DPYL-2, were highly related to ricin poisoning.<p />  <p>Language: en</p>
LA  - en
SN  - 1661-6596
UR  - http://dx.doi.org/10.3390/ijms15057281
ID  - ref1
ER  -