TY  - JOUR
PY  - 1979//
TI  - Liver injury by the false morel poison gyromitrin
JO  - Toxicology
A1  - Braun, R.
A1  - Greeff, U.
A1  - Netter, K. J.
SP  - 155
EP  - 163
VL  - 12
IS  - 2
N2  - After oral application of the mushroom poison gyromitrin a time and dose dependent decrease of cytochrome P-450 was found in rat liver microsomes. The maximal decrease to about 50-60% of the control (after 200 mg/kg, 80% of LD50) was observed 8-12h after application, a normalization after 48 h. The inhibition of cytochrome P-450 mediated metabolism of aminopyrine and p-nitroanisole corresponds to the decrease of cytochrome P-450. The specific activity of cytochrome P-450 remains unchanged while that of cytochrome P-448 is decreased as shown by means of the metabolism of ethoxycoumarin or ethoxyresorufin. Comparable results were obtained after application of N-methyl-N-formylhydrazine (MFH) which is formed from gyromitrin rapidly by hydrolysis. An attack on the endoplasmatic membrane with a stimulation of lipid peroxidation is discussed.<p /> <p>Language: en</p>
LA  - en
SN  - 0300-483X
UR  - http://dx.doi.org/
ID  - ref1
ER  -