TY - JOUR PY - 1978// TI - Hepatic injury in a child caused by trimethoprim-sulfamethoxazole JO - Pediatrics A1 - Stevenson, D. K. A1 - Christie, D. L. A1 - Haas, J. E. SP - 864 EP - 866 VL - 61 IS - 6 N2 - Trimethoprim-sulfamethoxazole was given to a 16-year-old boy as prophylaxis for a urinary tract infection. He developed severe cholestatic hepatitis 41 days after administration of the drug. A liver biopsy specimen showed a mixed inflammatory infiltrate in the portal triads and prominent bile stasis. The clinical course in this patient supports the concept of an indirect hypersensitivity reaction to sulfamethoxazole.
Language: en
LA - en SN - 0031-4005 UR - http://dx.doi.org/ ID - ref1 ER -