TY  - JOUR
PY  - 2014//
TI  - Alcohol dependence and reproductive timing in African and European ancestry women: findings in a midwestern twin cohort
JO  - Journal of studies on alcohol and drugs
A1  - Waldron, Mary
A1  - Bucholz, Kathleen K.
A1  - Madden, Pamela A. F.
A1  - Duncan, Alexis E.
A1  - Sartor, Carolyn E.
A1  - Heath, Andrew C.
SP  - 235
EP  - 240
VL  - 75
IS  - 2
N2  - OBJECTIVE: We examined associations between reproductive onset and history of alcohol dependence (AD) in 475 African ancestry (AA) and 2,865 European or other ancestry (EA) female twins. <br><br>METHOD: Participants were drawn from a U.S. midwestern birth cohort study of like-sex female twin pairs born between 1975 and 1985, ages 21-32 as of last completed assessment. Cox proportional hazards regression models were estimated predicting age at first childbirth from history of AD, separately by race/ethnicity, without and with adjustment for sociodemographic characteristics, body mass index, history of other substance involvement, psychopathology, and family and childhood risks. <br><br>RESULTS: Among EA twins, AD predicted early childbearing through age 17 and delayed childbearing from age 25 onward; in adjusted models, AD was associated with overall delayed childbearing. Among AA twins, reproductive timing and AD were not significantly related in either unadjusted or adjusted models. <br><br>CONCLUSIONS: Findings for twins of European ancestry are consistent with well-documented links between early alcohol mis/use and teenage parenting as well as delays in childbearing associated with drinking-related reproductive and relationship difficulties. Extension of analyses to other racial/ethnic groups of sufficient sample size remains important. (J. Stud. Alcohol Drugs, 75, 235-240, 2014).<p />  <p>Language: en</p>
LA  - en
SN  - 1937-1888
UR  - http://dx.doi.org/
ID  - ref1
ER  -