TY  - JOUR
PY  - 1996//
TI  - The safety effects of child-resistant packaging for oral prescription drugs. two decades of experience
JO  - JAMA journal of the American Medical Association
A1  - Rodgers, Gregory B.
SP  - 1661
EP  - 1665
VL  - 275
IS  - 21
N2  - OBJECTIVE--To evaluate the effectiveness of child-resistant packaging in reducing the mortality rate for children younger than 5 years from the unintentional ingestion of oral prescription drugs. DESIGN--Annual mortality rates for children younger than 5 years associated with the unintentional ingestion of oral prescription drugs are constructed for 1964 through 1992. The effect of child-resistant packaging on the child mortality rate during the postintervention period (1974 through 1992) is evaluated with a multivariate time series regression model. The analysis controls for changes in the consumption of oral prescription drugs over time and for long-term safety trends. SETTING--United States. SUBJECTS--Children younger than 5 years. MAIN OUTCOME MEASURE--Estimated reductions in the child mortality rate associated with the use of child-resistant packaging. RESULTS--After controlling for covariates, the use of child-resistant packaging was associated with an annual reduction in the oral prescription drug-related mortality rate of 1.40 (95% confidence interval, 0.85-1.95) deaths per million children younger than 5 years. This suggests a reduction of about 460 child deaths from 1974, the year oral prescription drugs became subject to child-resistant packaging requirements, through 1992-a mortality rate reduction of about 45% from levels projected without the child-resistant requirements. CONCLUSION--Child-resistant packaging reduces child mortality from the unintentional ingestion of oral prescription drugs.<p />  <p>Language: en</p>
LA  - en
SN  - 0098-7484
UR  - http://dx.doi.org/
ID  - ref1
ER  -