TY  - JOUR
PY  - 2003//
TI  - A rare fatality attributed to an overdose of Cimetidine
JO  - Journal (Canadian Society of Forensic Science)
A1  - Jones, G. R.
A1  - Singer, P. P.
SP  - 73
EP  - 76
VL  - 36
IS  - 2
N2  - A 39-year-old woman died after consuming an overdose of Cimetidine. Concentrations of Cimetidine found were femoral blood 310 mg/L, vitreous humor 52 mg/L, bile 1700 mg/L, liver 436 mg/kg, urine 1400 mg/L and gastric 2850 mg/total contents provided. The only other significant toxicology findings were ethanol: blood 110 mg/100 mL, vitreous 140 mg/100 mL and urine 150 mg/100 mL). At autopsy the woman was also found to have cardiac hypertrophy and micronodular cirrhosis. Cimetidine was determined by high performance liquid chromatography using a CN-Spherisorb 15 cm length, × 4 mm i.d. column using ranitidine as the internal standard. The mobile phase was 0.005M sodium dihydrogen phosphase (pH 4.6) and acetonitriie (50:50). Extraction of the Cimetidine and internal standard was performed with dichloromethane: isopropanol (9:1) after basifying the blood or other sample with 2N sodium hydroxide.<p />
LA  - en
SN  - 0008-5030
UR  - http://dx.doi.org/10.1080/00085030.2003.10757554
ID  - ref1
ER  -