TY  - JOUR
PY  - 2014//
TI  - A diffusion tensor imaging study of suicide attempters
JO  - Journal of psychiatric research
A1  - Olvet, Doreen M.
A1  - Peruzzo, Denis
A1  - Thapa-Chhetry, Binod
A1  - Sublette, M. Elizabeth
A1  - Sullivan, Gregory M.
A1  - Oquendo, Maria A.
A1  - Mann, J. John
A1  - Parsey, Ramin V.
SP  - 60
EP  - 67
VL  - 51
IS  - 
N2  - BACKGROUND: Few studies have examined white matter abnormalities in suicide attempters using diffusion tensor imaging (DTI). This study sought to identify white matter regions altered in individuals with a prior suicide attempt. METHODS: DTI scans were acquired in 13 suicide attempters with major depressive disorder (MDD), 39 non-attempters with MDD, and 46 healthy participants (HP). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were determined in the brain using two methods: region of interest (ROI) and tract-based spatial statistics (TBSS). ROIs were limited a priori to white matter adjacent to the caudal anterior cingulate cortex, rostral anterior cingulate cortex, dorsomedial prefrontal cortex, and medial orbitofrontal cortex. RESULTS: Using the ROI approach, suicide attempters had lower FA than MDD non-attempters and HP in the dorsomedial prefrontal cortex. Uncorrected TBSS results confirmed a significant cluster within the right dorsomedial prefrontal cortex indicating lower FA in suicide attempters compared to non-attempters. There were no differences in ADC when comparing suicide attempters, non-attempters and HP groups using ROI or TBSS methods. CONCLUSIONS: Low FA in the dorsomedial prefrontal cortex was associated with a suicide attempt history. Converging findings from other imaging modalities support this finding, making this region of potential interest in determining the diathesis for suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2014.01.002
ID  - ref1
ER  -