TY  - JOUR
PY  - 1977//
TI  - The influence of temperature of ingested fluid on stomach emptying time
JO  - International journal of clinical pharmacology and biopharmacy
A1  - Ritschel, W. A.
A1  - Erni, W.
SP  - 172
EP  - 175
VL  - 15
IS  - 4
N2  - The influence of the temperature of ingested water on the stomach emptying time of solid material was studied in healthy volunteers using a telemetric pH measurement device. The time of discharge of the indigestible capsule from the stomach into the duodenum is statistically faster when administered with 250 ml of water at 5 degrees C, 15.91+/-10.04 min. (mean+/-SD) than it is with water at 20-25 degrees C, 48.18+/-28.97 min (mean+/-SD) or at 45 degrees C 71.42+/-37.08 min. (mean+/-SD). It seems that the interindividual variation is larger than the intra-individual one. These observations suggest that enteric coated preparations and drugs which are inactivated by gastric fluid or irritate gastric mucosa should be administered only with ice water (4-6 degrees C), and stomach washings (with charcoal) in order to remove a poisoning agent should be performed with warm water (45 degrees C).<p /> <p>Language: en</p>
LA  - en
SN  - 0340-0026
UR  - http://dx.doi.org/
ID  - ref1
ER  -