TY  - JOUR
PY  - 2014//
TI  - Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial
JO  - Journals of gerontology. Series A: Biological sciences and medical sciences
A1  - Sumukadas, Deepa
A1  - Cvoro, Vera
A1  - Miller, Suzanne
A1  - Band, Margaret
A1  - McMurdo, Marion
A1  - Struthers, Allan
A1  - Witham, Miles
A1  - Lloyd, Suzanne M.
A1  - McConnachie, Alex
SP  - 736
EP  - 743
VL  - 69
IS  - 6
N2  - BACKGROUND: Loss of muscle mass and strength with ageing is a major cause for falls, disability, and morbidity in older people. Previous studies have found that angiotensin-converting enzyme inhibitors (ACEi) may improve physical function in older people. It is unclear whether ACEi provide additional benefit when added to a standard exercise training program. We examined the effects of ACEi therapy on physical function in older people undergoing exercise training. METHODS: Community-dwelling people aged ≥65 years with functional impairment were recruited through general (family) practices. All participants received progressive exercise training. Participants were randomized to receive either 4 mg perindopril or matching placebo daily for 20 weeks. The primary outcome was between-group change in 6-minute walk distance from baseline to 20 weeks. Secondary outcomes included changes in Short Physical Performance Battery, handgrip and quadriceps strength, self-reported quality of life using the EQ-5D, and functional impairment measured using the Functional Limitations Profile. RESULTS: A total of 170 participants (n = 86 perindopril, n = 84 placebo) were randomized. Mean age was 75.7 (standard deviation [SD] 6.8) years. Baseline 6-minute walk distance was 306 m (SD 99). Both groups increased their walk distance (by 29.6 m perindopril, 36.4 m placebo group) at 20 weeks, but there was no statistically significant treatment effect between groups (-8.6m [95% confidence interval: -30.1, 12.9], p = .43). No statistically significant treatment effects were observed between groups for the secondary outcomes. Adverse events leading to withdrawal were few (n = 0 perindopril, n = 4 placebo).Interpretation.ACE inhibitors did not enhance the effect of exercise training on physical function in functionally impaired older people.<p />  <p>Language: en</p>
LA  - en
SN  - 1079-5006
UR  - http://dx.doi.org/10.1093/gerona/glt142
ID  - ref1
ER  -