TY  - JOUR
PY  - 2014//
TI  - Interpretation of pharmaceutical drug concentrations in young children's head hair
JO  - Journal of forensic sciences
A1  - Chatterton, Craig
A1  - Turner, Kirsten
A1  - Klinger, Nadine
A1  - Etter, Matthieu
A1  - Duez, Mathieu
A1  - Cirimele, Vincent
SP  - 281
EP  - 286
VL  - 59
IS  - 1
N2  - Three separate cases of child administration of prescription drugs are described. Following liquid-liquid extraction, high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was used to identify and quantify methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenyl-1-pyrrolidine (EDDP), tramadol, amitriptyline, and nortriptyline in children's hair. The children's age ranged from 14 months to 7 years; in all three cases, the drug in question was detected in more than one section of hair. Methadone was detected in the concentration range of 0.65-0.99 and 0.04-0.4 ng/mg; tramadol was detected in the concentration range of 1.5-2.2 ng/mg; amitriptyline and nortriptyline were detected in the concentration range of 0.18-1.06 and 0.38-2.0 ng/mg, respectively. In each case, the children's parents admitted to or were found guilty of drug administration to the child. These cases demonstrate the added value of hair testing and emphasize the importance of using hair samples to complement conventional analyses.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-1198
UR  - http://dx.doi.org/10.1111/1556-4029.12301
ID  - ref1
ER  -