TY  - JOUR
PY  - 2013//
TI  - Microglial activation of p38 contributes to scorpion envenomation-induced hyperalgesia
JO  - Biochemical and biophysical research communications
A1  - Niu, Qing-Shan
A1  - Jiang, Feng
A1  - Hua, Li-Ming
A1  - Fu, Jin
A1  - Jiao, Yun-Lu
A1  - Ji, Yong-Hua
A1  - Ding, Gang
SP  - 374
EP  - 380
VL  - 440
IS  - 3
N2  - Intraplantar (i.pl.) injection of BmK I, a receptor site 3-specific modulator of voltage-gated sodium channels (VGSCs) from the venom of scorpion Buthus martensi Karsch (BMK), was shown to induce long-lasting and spontaneous nociceptive responses as demonstrated through experiments utilizing primary thermal and mirror-imaged mechanical hypersensitivity with different time course of development in rats. In this study, microglia was activated on both sides of L4-L5 spinal cord by i.pl. injection of BmK I. Meanwhile, the activation of p38/MAPK in L4-L5 spinal cord was found to be co-expressed with OX-42, the cell marker of microglia. The unilateral thermal and bilateral mechanical pain hypersensitivity of rat induced by BmK I was suppressed in a dose-dependent manner following pretreatment with SB203580 (a specific inhibitor of p-p38). Interestingly, microglia activity was also reduced in the presence of SB203580, which suggests that BmK I-induced microglial activation is mediated by p38/MAPK pathway. Combined with previously published literature, the results of this study demonstrate that p38-dependent microglial activation plays a role in scorpion envenomation-induced pain-related behaviors.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-291X
UR  - http://dx.doi.org/10.1016/j.bbrc.2013.09.071
ID  - ref1
ER  -