TY  - JOUR
PY  - 2013//
TI  - The fallacy of thresholds used in defining response and remission in depression rating scales
JO  - International journal of methods in psychiatric research
A1  - Naudet, Florian
A1  - Millet, Bruno
A1  - Michel Reymann, Jean
A1  - Falissard, Bruno
SP  - 469
EP  - 473
VL  - 23
IS  - 4
N2  - Response and remission are determined by the proportion of people who fall below a threshold score on depression rating scales. This calculation implies a possibility of false positives (FP) and false negatives (FN) depending on sensitivity and specificity of the threshold used, but also on response and remission rates. A simulation illustrates the methodological consequences of this phenomenon in a comparative trial where response and remission rates differ between groups: the probability of being misclassified differs between groups, and measures of association (relative risk and odds ratio) are biased. Alternatives are proposed to cope with this misclassification bias. Copyright © 2013 John Wiley & Sons, Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 1049-8931
UR  - http://dx.doi.org/10.1002/mpr.1393
ID  - ref1
ER  -