TY  - JOUR
PY  - 2014//
TI  - Cortical and cerebellar modulation of autonomic responses to loud sounds
JO  - Psychophysiology
A1  - Mueller-Pfeiffer, Christoph
A1  - Zeffiro, Thomas
A1  - O'Gorman, Ruth
A1  - Michels, Lars
A1  - Baumann, Peter
A1  - Wood, Nellie
A1  - Spring, Justin
A1  - Rufer, Michael
A1  - Pitman, Roger K.
A1  - Orr, Scott P.
SP  - 60
EP  - 69
VL  - 51
IS  - 1
N2  - Detecting unexpected environmental change causes modulation of autonomic activity essential for survival. Understanding the neural mechanisms associated with responses to loud sounds may provide insights into the pathophysiology of posttraumatic stress disorder (PTSD), since individuals with PTSD exhibit heightened autonomic responses to unexpected loud sounds. We combined fMRI with autonomic psychophysiological assessment to investigate central and peripheral reactivity to loud tones in 20 healthy participants. Activity in anterior insula, pregenual anterior cingulate cortex, anterior midcingulate cortex, supplementary motor area, supramarginal gyrus, and cerebellar lobules VIII-IX was associated with both tones and concomitant skin conductance responses. Since regions signaling unexpected external events modulate autonomic activity, heightened loud tone autonomic responses in PTSD may reflect sensitization of this "salience" network.<p />  <p>Language: en</p>
LA  - en
SN  - 0048-5772
UR  - http://dx.doi.org/10.1111/psyp.12142
ID  - ref1
ER  -