TY  - JOUR
PY  - 2013//
TI  - The influence of hemocoagulation disorders on the development of posttraumatic cerebral infarction and outcome in patients with moderate or severe head trauma
JO  - BioMed research international
A1  - Chen, Hao
A1  - Xue, Li-Xia
A1  - Guo, Yan
A1  - Chen, Shih-Wen
A1  - Wang, Gan
A1  - Cao, He-Li
A1  - Chen, Jiong
A1  - Tian, Heng-Li
SP  - 685174
EP  - 685174
VL  - 2013
IS  - 
N2  - Posttraumatic cerebral infarction (PTCI) is a severe secondary insult of head injury and often leads to a poor prognosis. Hemocoagulation disorder is recognized to have important effects on hemorrhagic or ischemic damages. We sought to assess if posttraumatic hemocoagulation disorders were associated with cerebral infarction, and evaluate their influence on outcome among patients with moderate or severe head trauma. In this study, PTCI was observed in 28 (10.57%) of the 265 patients within the first week after injury. In multivariate analysis, the thrombocytopenia (odds ratio (OR) 2.210, 95% confidence interval (CI) 1.065-4.674), abnormal prothrombin time (PT) (OR 3.241, 95% CI 1.090-7.648), D-dimer (>2 mg/L) (OR 7.260, 95% CI 1.822-28.076), or disseminated intravascular coagulation (DIC) scores (≥5) (OR 4.717, 95% CI 1.778-12.517) were each independently associated with an increased risk of PTCI. Admission Glasgow Coma Scale (GCS) score, abnormal activated partial thromboplastin time (APTT) and fibrinogen, and D-dimer (>2 mg/L) and DIC scores (≥5) showed an independent predictive effect on poor outcome. In conclusion, recognition of this important treatable cause of PTCI and the associated risk factors may help identify the group at risk and tailor management of patients with TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 2314-6133
UR  - http://dx.doi.org/10.1155/2013/685174
ID  - ref1
ER  -