TY  - JOUR
PY  - 2013//
TI  - Individual participant data meta-analyses should not ignore clustering
JO  - Journal of clinical epidemiology
A1  - Abo-Zaid, Ghada
A1  - Guo, Boliang
A1  - Deeks, Jonathan J.
A1  - Debray, Thomas P. A.
A1  - Steyerberg, Ewout W.
A1  - Moons, Karel G. M.
A1  - Riley, Richard David
SP  - 865
EP  - 873.e4
VL  - 66
IS  - 8
N2  - OBJECTIVES: Individual participant data (IPD) meta-analyses often analyze their IPD as if coming from a single study. We compare this approach with analyses that rather account for clustering of patients within studies. STUDY DESIGN AND SETTING: Comparison of effect estimates from logistic regression models in real and simulated examples. RESULTS: The estimated prognostic effect of age in patients with traumatic brain injury is similar, regardless of whether clustering is accounted for. However, a family history of thrombophilia is found to be a diagnostic marker of deep vein thrombosis [odds ratio, 1.30; 95% confidence interval (CI): 1.00, 1.70; P = 0.05] when clustering is accounted for but not when it is ignored (odds ratio, 1.06; 95% CI: 0.83, 1.37; P = 0.64). Similarly, the treatment effect of nicotine gum on smoking cessation is severely attenuated when clustering is ignored (odds ratio, 1.40; 95% CI: 1.02, 1.92) rather than accounted for (odds ratio, 1.80; 95% CI: 1.29, 2.52). Simulations show models accounting for clustering perform consistently well, but downwardly biased effect estimates and low coverage can occur when ignoring clustering. CONCLUSION: Researchers must routinely account for clustering in IPD meta-analyses; otherwise, misleading effect estimates and conclusions may arise.<p />  <p>Language: en</p>
LA  - en
SN  - 0895-4356
UR  - http://dx.doi.org/10.1016/j.jclinepi.2012.12.017
ID  - ref1
ER  -