TY  - JOUR
PY  - 2013//
TI  - Serial ricinine levels in serum and urine after ricin intoxication
JO  - Journal of analytical toxicology
A1  - Røen, Bent Tore
A1  - Opstad, Aase Mari
A1  - Haavind, Anniken
A1  - Tønsager, Janne
SP  - 313
EP  - 317
VL  - 37
IS  - 5
N2  - Ricinine is an alkaloid present in the castor bean plant (Ricinus communis) that can be used as a biomarker for ricin poisoning. Serial ricinine levels are reported in the serum and urine of a patient suffering from intentional ricin intoxication. The patient was brought to the hospital 4 h after injection and oral intake of a castor bean extract, but died 38 h later, despite intensive medical care. Ricinine was isolated from the samples by solid-phase extraction and quantitatively determined by isotopic dilution liquid chromatography-mass spectrometry. The ricinine level in serum declined from 33 to 23 ng/mL between 10 and 29 h post-exposure. Three urine samples collected from 12 to 41 h after ricin intoxication showed ricinine concentrations in the range of 20-58 ng/mL. The creatinine corrected values (21-30 µg/g) indicated a concentration-time profile with a maximum ricinine level in urine between 12 and 29 h after exposure.<p />  <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/bkt026
ID  - ref1
ER  -