TY  - JOUR
PY  - 2013//
TI  - Alcohol hangover: type and time-extension of motor function impairments
JO  - Behavioural brain research
A1  - Karadayian, Analía G.
A1  - Cutrera, Rodolfo A.
SP  - 165
EP  - 173
VL  - 247
IS  - 
N2  - Alcohol hangover is defined as the unpleasant next-day state following an evening of excessive alcohol consumption. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. During hangover cognitive functions and subjective capacities are affected along with inefficiency, reduced productivity, absenteeism, driving impairments, poor academic achievement and reductions in motor coordination. The aim of this work was to study the type and length of motor and exploratory functions from the beginning to the end of the alcohol hangover. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8g/kg BW) (hangover group). Motor performance, walking deficiency, motor strength, locomotion and exploratory activity were evaluated at a basal point (ZT0) and every 2hours up to 20hours after blood alcohol levels were close to zero (hangover onset). Motor performance was 80% decreased at the onset of hangover (p<0.001). Hangover mice exhibited a reduced motor performance during the next 16hours (p<0.01). Motor function was recovered 20hours after hangover onset. Hangover mice displayed walking deficiencies from the beginning to 16hours after hangover onset (P<0.05). Moreover, mice suffering from a hangover, exhibited a significant decrease in neuromuscular strength during 16hours (p<0.001). Averaged speed and total distance travelled in the open field test and the exploratory activity on t-maze and hole board tests were reduced during 16hours after hangover onset (P<0.05). Our findings demonstrate a time-extension between 16 to 20hours for hangover motor and exploratory impairments. As a whole, this study shows the long lasting effects of alcohol hangover.<p />  <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/10.1016/j.bbr.2013.03.037
ID  - ref1
ER  -