TY  - JOUR
PY  - 2004//
TI  - Determination of burn depth by polarization-sensitive optical coherence tomography
JO  - Journal of biomedical optics
A1  - Srinivas, Shyam M.
A1  - de Boer, Johannes F.
A1  - Park, Hyle
A1  - Keikhanzadeh, Kourosh
A1  - Huang, Huai-en L.
A1  - Zhang, Jun
A1  - Jung, Woong Qyu
A1  - Chen, Zhongping
A1  - Nelson, J. Stuart
SP  - 207
EP  - 212
VL  - 9
IS  - 1
N2  - An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 degrees C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/microm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients.<p /> <p>Language: en</p>
LA  - en
SN  - 1083-3668
UR  - http://dx.doi.org/10.1117/1.1629680
ID  - ref1
ER  -