TY  - JOUR
PY  - 2012//
TI  - Fatal metformin intoxication with markedly elevated blood and liver concentrations
JO  - Journal of analytical toxicology
A1  - Cantrell, F. Lee
A1  - Nelson, Craig L.
A1  - Gary, Ray D.
A1  - McIntyre, Iain M.
SP  - 657
EP  - 659
VL  - 36
IS  - 9
N2  - Metformin (Glucophage) is a medication used to treat Type 2 diabetes. The highest postmortem metformin concentrations are recorded utilizing a sensitive and specific analytical procedure. The peripheral blood metformin concentration was 240 mg/L, the liver concentration was 240 mg/kg and the gastric concentration was 1,700 mg. Additionally, an antemortem blood sample collected shortly after admission revealed a metformin concentration of 210 mg/L. These data, revealing a liver to peripheral blood ratio of 1.0, provide additional support that metformin is not subject to postmortem redistribution. Intentional self-poisonings with metformin can result in death, despite multiple medical interventions.<p />  <p>Language: en</p>
LA  - en
SN  - 0146-4760
UR  - http://dx.doi.org/10.1093/jat/bks076
ID  - ref1
ER  -