TY  - JOUR
PY  - 2006//
TI  - Interaction of raclopride and preparatory interval effects on simple reaction time performance
JO  - Behavioural brain research
A1  - Macdonald, Christopher J.
A1  - Meck, Warren H.
SP  - 62
EP  - 74
VL  - 175
IS  - 1
N2  - In a series of three experiments, simple reaction time (RT) was characterized with respect to a variable preparatory interval (PI) in order to investigate the relationship between interval timing and RT. In Experiment 1, it was shown that RT decreases as a function of PI and that this effect varies with amount of training. In Experiment 2, RT was shown to increase during probe trials that used a novel 6.25s PI, suggesting that the specific durations of the PIs encoded during initial training contribute to the PI effect on RT. In Experiment 3, 100 microg/kg i.p. of raclopride proportionally slowed RT as a function of the PI. These results are discussed within the context of neuropsychological models of interval timing and support an underlying role for cortico-striatal dopaminergic function in temporal processing and simple RT measurements.<p /> <p>Language: en</p>
LA  - en
SN  - 0166-4328
UR  - http://dx.doi.org/10.1016/j.bbr.2006.08.004
ID  - ref1
ER  -