TY  - JOUR
PY  - 2012//
TI  - Coma blisters after poisoning caused by central nervous system depressants: case report including histopathological findings
JO  - Anais Brasileiros de Dermatologia
A1  - Branco, Maí­ra Migliari
A1  - Capitani, Eduardo Mello de
A1  - Cintra, Maria Letícia
A1  - Hyslop, Stephen
A1  - Carvalho, Adriana Camargo
A1  - Bucaretchi, Fábio
SP  - 615
EP  - 617
VL  - 87
IS  - 4
N2  - Blister formation and eccrine sweat gland necrosis is a cutaneous manifestation associated with states of impaired consciousness, most frequently reported after overdoses of central nervous system depressants, particularly phenobarbital. The case of a 45-year-old woman who developed "coma blisters" at six distinct anatomic sites after confirmed (laboratory) phenobarbital poisoning, associated with other central nervous system depressants (clonazepam, promethazine, oxcarbazepine and quetiapine), is presented. A biopsy from the left thumb blister taken on day 4 revealed focal necrosis of the epidermis and necrosis of sweat gland epithelial cells; direct immunofluorescence was strongly positive for IgG in superficial blood vessel walls but negative for IgM, IgA, C3 and C1q. The patient was discharged on day 21 with no sequelae.<p />  <p>Language: en</p>
LA  - en
SN  - 0365-0596
UR  - http://dx.doi.org/
ID  - ref1
ER  -