TY  - JOUR
PY  - 2011//
TI  - Oxytocin receptor gene (OXTR) is related to psychological resources
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Saphire-Bernstein, Shimon
A1  - Way, Baldwin M.
A1  - Kim, Heejung S.
A1  - Sherman, David K.
A1  - Taylor, Shelley E.
SP  - 15118
EP  - 15122
VL  - 108
IS  - 37
N2  - Psychological resources--optimism, mastery, and self-esteem--buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.<p /> <p>Language: en</p> 
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.1113137108
ID  - ref1
ER  -