TY  - JOUR
PY  - 2011//
TI  - Role of mother's genes and environment in postpartum depression
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Mitchell, Colter
A1  - Notterman, Daniel
A1  - Brooks-Gunn, Jeanne
A1  - Hobcraft, John
A1  - Garfinkel, Irwin
A1  - Jaeger, Kate
A1  - Kotenko, Iulia
A1  - McLanahan, Sara
SP  - 8189
EP  - 8193
VL  - 108
IS  - 20
N2  - Most studies of human molecular genetics and social environment interactions on health have relied heavily on the classic diathesis-stress model that treats genetic variations and environments as being either "risky" or "protective." The biological susceptibility model posits that some individuals have greater genetic reactivity to stress, leading to worse outcomes in poor environments, but better outcomes in rich environments. Using a nontruncated measure of a chronic environmental stressor--socioeconomic status--measured by education, and two polymorphisms (5-HTTLPR and STin2 VNTR) of the serotonin transporter gene (5-HTT), we find strong evidence that some women are genetically more reactive to the environment, resulting in a crossover of risks of postpartum depression for the most reactive groups. We discuss how our approach and findings provide a framework for understanding some of the confusion in the gene-environment interaction literature on stress, 5-HTT, and depression.<p /> <p>Language: en</p> 
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.1014129108
ID  - ref1
ER  -