TY  - JOUR
PY  - 2012//
TI  - Negative and competitive social interactions are related to heightened proinflammatory cytokine activity
JO  - Proceedings of the National Academy of Sciences of the United States of America
A1  - Chiang, Jessica J.
A1  - Eisenberger, Naomi I.
A1  - Seeman, Teresa E.
A1  - Taylor, Shelley E.
SP  - 1878
EP  - 1882
VL  - 109
IS  - 6
N2  - Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.<p />  <p>Language: en</p>
LA  - en
SN  - 0027-8424
UR  - http://dx.doi.org/10.1073/pnas.1120972109
ID  - ref1
ER  -