TY  - JOUR
PY  - 2002//
TI  - Possibilities and limits of treatment of aggressive behavior in patients with mental retardation with risperidone
JO  - Nervenarzt
A1  - Hässler, F.
A1  - Buchmann, J.
A1  - Bohne, S.
SP  - 278
EP  - 282
VL  - 73
IS  - 3
N2  - Despite definite indication for psychopharmacologic intervention, severe and persistent symptoms of aggressive and self-injurious behaviour still remain a therapeutic challenge. As recent research has demonstrated, not only the dopaminergic and serotonergic but also the endogenous opiate system plays a role in the pathogenesis of self-injurious behaviour. Nevertheless, the efficacy of classical neuroleptics as well as opiate antagonists is questioned. In open and controlled studies, the administration of the atypical neuroleptic risperidone (a serotonin 2A-dopamine D2 antagonist) was associated with a long-term effect in reducing self-injuries. In our clinical trial, 20 mentally retarded adults presenting with severe self-injurious and aggressive behaviour were administered risperidone over a follow-up period of 35 months. Clinical efficacy was measured with the Disability Assessment Schedule (DAS), conducted in a home for people with mental retardation. In 17 patients, a significant reduction in self-injurious behaviour is shown. Besides, there was a significant overall clinical improvement in behaviour.<p /> <p>Language: de</p>
LA  - de
SN  - 0028-2804
UR  - http://dx.doi.org/
ID  - ref1
ER  -