TY  - JOUR
PY  - 2002//
TI  - Acute performance-impairing and subject-rated effects of triazolam and temazepam, alone and in combination with ethanol, in humans
JO  - Journal of psychopharmacology
A1  - Simpson, Cathy A.
A1  - Rush, Craig R.
SP  - 23
EP  - 34
VL  - 16
IS  - 1
N2  - The acute behavioural effects of triazolam (0.125 and 0.25 mg), temazepam (15 and 30 mg), and placebo, alone and in combination with ethanol (0 and 0.5 g/kg), were assessed in 10 volunteers. Ethanol alone did not impair performance and produced only a few subject-rated drug effects. Triazolam and temazepam alone produced some performance impairment and a few subject-rated drug effects. These effects tended to be dose-dependent and were comparable for the two drugs across the range of doses tested. The triazolam-ethanol and temazepam-ethanol combinations produced robust performance impairment and sedative-like subject-rated drug effects that were similar in magnitude. The findings of the present study suggest that even a moderate amount of ethanol in combination with a clinical dose of triazolam or temazepam can cause performance impairment that might diminish an individual's ability to respond adequately to unexpected demands (e.g. smoke alarms or middle-of-the-night child care).<p /> <p>Language: en</p>
LA  - en
SN  - 0269-8811
UR  - http://dx.doi.org/
ID  - ref1
ER  -