TY - JOUR PY - 2011// TI - Dysfunctional impulsivity in schizophrenia: a functional MRI investigation JO - European psychiatry A1 - Kumari, V. A1 - Raghuvanshi, S. A1 - Sumich, A. A1 - Barkataki, I. A1 - Taylor, P. A1 - Williams, S. A1 - Das, M. SP - 1426 EP - 1426 VL - 26 IS - Suppl 1 N2 - Introduction Dysfunctional impulsivity reflects 'recklessness without deliberation and evaluation of consequences' and has negative consequences whereas functional impulsivity reflects 'rapid responding to situational demands in order to maximise one's circumstances' and often has positive consequences (1). Objective To examine the functional brain basis of dysfunctional impulsivity in healthy people and in people with schizophrenia. Methods Thirteen healthy controls and 21 schizophrenia patients (10/21 with serious repetitive violence) underwent fMRI during a Go/ NoGo task. Dysfunctional impulsivity was indexed using the Impulsiveness subscale and functional impulsivity using the Venturesomeness subscale of the Impulsiveness-Venturesomeness-Empathy questionnaire (2). Results Violent patients had elevated Impulsiveness scores relative to non-violent patients and controls. Impulsiveness did not correlate significantly with task performance in healthy controls or patients. Impulsiveness, but not Venturesomeness, scores correlated during the NoGO condition with lower activity in the anterior cingulate (AC) in controls, and lower inferior temporal and hippocampal activity in patients. Conclusions These findings accord with previously reported associations between reduced hippocampal volume and dysfunctional impulsivity in schizophrenia (3) and, combined with our earlier observations of reduced AC activation during a working memory task in violent antisocial individuals (4), suggest that the influence of dysfunctional impulsivity in antisocial and criminal behaviour is mediated via deficient (inhibitory) functions of the AC and hippocampus.

LA - SN - 0924-9338 UR - http://dx.doi.org/10.1016/S0924-9338(11)73131-5 ID - ref1 ER -