TY  - JOUR
PY  - 2012//
TI  - Protection of Mice against X-ray Injuries by the Post-irradiation Administration of Inosine-5'-monophosphate
JO  - Journal of radiation research
A1  - Asadullina, Nelli R.
A1  - Usacheva, Anna M.
A1  - Gudkov, Sergey V.
SP  - 211
EP  - 216
VL  - 53
IS  - 2
N2  - The aim of the present study was to investigate the radiation modulating properties of inosine-5'-monophosphate (IMP). Mice injected introperitoneally (i.p.) with IMP 15 minutes after irradiation with a lethal irradiation dose of 7 Gy have better survival rates comparative to irradiated mice non treated with IMP. The dose reduction factor of the IMP is 1.22. Using a hematologdical test we demonstrated that administration of IMP alleviates the symptoms of radiation-induced leukopenia and thrombocytopenia. The DNA damage in bone marrow and thymus cells of irradiated mice was measured by flow cytofluorometry and micronucleus test (MN-test). The tests show that i.p. administration of IMP to irradiated animals leads to a significant reduction of the DNA damage level. In this paper we show that IMP substantially modulates the damaging effects of ionizing radiation protecting irradiated mice and it is a promising agent for a treatment of leukopenia.<p />  <p>Language: en</p>
LA  - en
SN  - 0449-3060
UR  - http://dx.doi.org/
ID  - ref1
ER  -