TY  - JOUR
PY  - 2012//
TI  - Estimation of the duration after methamphetamine injection using a pharmacokinetic model in suspects who caused fatal traffic accidents
JO  - Legal medicine (Elsevier)
A1  - Matsubara, Kazuo
A1  - Asari, Masaru
A1  - Suno, Manabu
A1  - Awaya, Toshio
A1  - Sugawara, Mitsuru
A1  - Omura, Tomohiro
A1  - Yamamoto, Joe
A1  - Maseda, Chikatoshi
A1  - Tasaki, Yoshikazu
A1  - Shiono, Hiroshi
A1  - Shimizu, Keiko
SP  - 191
EP  - 196
VL  - 14
IS  - 4
N2  - When the population parameters of drug pharmacokinetics in the human body system are known, the time-course of a certain drug in an individual can generally be estimated by pharmacokinetics. In the present two cases where methamphetamine abusers were suspected to have inflicted mortalities in traffic accidents, the time-elapse or duration immediately after methamphetamine injection to the time when the accidents occurred became points of contention. In each case, we estimated the time-course of blood methamphetamine after the self-administration in the suspects using a 2-compartment pharmacokinetic model with known pharmacokinetic parameters from the literatures. If the injected amount can be determined to a certain extent, it is easy to calculate the average time-elapse after injection by referring to reference values. However, there is considerable individual variability in the elimination rate based on genetic polymorphism and a considerably large error range in the estimated time-elapse results. To minimize estimation errors in such cases, we also analyzed genotype of CYP2D6, which influenced methamphetamine metabolism. Estimation based on two time-point blood samples would usefully benefit legal authorities in passing ruling sentences in cases involving similar personalities and circumstances as those involved in the present study.<p />  <p>Language: en</p>
LA  - en
SN  - 1344-6223
UR  - http://dx.doi.org/10.1016/j.legalmed.2012.01.013
ID  - ref1
ER  -