TY  - JOUR
PY  - 2002//
TI  - Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema
JO  - Annals of neurology
A1  - Lynch, John R.
A1  - Pineda, Jose A.
A1  - Morgan, Duncan
A1  - Zhang, Lin
A1  - Warner, David S.
A1  - Benveniste, Helen
A1  - Laskowitz, Daniel T.
SP  - 113
EP  - 117
VL  - 51
IS  - 1
N2  - Apolipoprotein E has been implicated in modifying neurological outcome after traumatic brain injury, although the mechanisms by which this occurs remain poorly defined. To investigate the role of endogenous apolipoprotein E following acute brain injury, noninvasive magnetic resonance imaging was performed on anesthetized mice following closed head injury. Effacement of the lateral ventricle was used as a radiographic surrogate for cerebral edema. At 24 hours following injury, apolipoprotein E-deficient animals had a greater degree of cerebral edema as compared to matched controls. In addition, the brains of apolipoprotein E-deficient animals had a significantly greater upregulation of tissue necrosis factor alpha messenger ribonucleic acid as compared to controls as early as 1-hr post injury. Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury.<p /> <p>Language: en</p>
LA  - en
SN  - 0364-5134
UR  - http://dx.doi.org/
ID  - ref1
ER  -